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There is ongoing debate about cardiovascular risks: some studies have suggested that testosterone treatment might be associated with a higher incidence of heart attack or stroke in older men, though definitive evidence is inconclusive

Sriwastava S, Sharma K, Khalid SH, Bhansali S, Shrestha AK, Elkhooly M, Srivastava S, et al

MOTS-c is the other common pairing in laboratory work on energy metabolism, since it acts on mitochondrial pathways and insulin sensitivity rather than on adrenergic receptors