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In multiple preclinical studies, elevated NNMT activity has been associated with altered NAD pools and changes in cellular energy efficiency, particularly in adipose tissue and liver

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Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation

In this article, Abba Kastin and colleagues review the known effects of DSIP and argue that further work is needed before it can be considered functional