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Cellular iron uptake is largely mediated by the binding of serum transferrin to transferrin receptor 1 ( TFR1 ) and subsequent endocytosis ( TFR1 facilitates external iron acquisition, while the divalent metal transporter promotes intracellular iron release and ferroportin exports iron under hepatic regulation ( Degradation of the iron storage protein ferritin occurs via NCOA4- mediated ferritinophagy, releasing free iron that directly fuels the Fenton reaction

To verify the proposed mechanism of action of NMN, we studied longterm NMN supplementation and its impact on ovarian health and discovered that NMN helps prevent ovarian atrophy

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