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The increase in oxidative stress is commonly reported in Alzheimers disease ( Association of memory loss with a parallel increase in the expression of APP in the brain of diabetic control mice suggests an association with Alzheimers disease in the diabetes model

Blood samples for pharmacokinetic analysis were collected up to 15 min pre-dose (day 1), and at 4, 8, 12, 18, 24, 30, 36, 48, 54, 60, 72, 84, 96 and 120 h post-dose