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Systemic iron homeostasis must be preserved during chelation therapy, as excessive iron depletion can lead to anemia and other adverse effects (310)

doi: 10.1016/0140-6736(91)91846-m 183 UrazS.TahanG.AytekinH.TahanV

These results led to accelerated approval of lifileucel (AMTAGVI) by the United States Food and Drug Administration (FDA) in 2024 for adults with unresectable or metastatic melanoma previously treated with a PD-1 inhibitor and, if BRAF V600 -mutated, an appropriate BRAF-targeted regimen, making it the first approved TIL therapy for a solid tumor [81]

Although the scientific evidence linking acetaminophen to autism and ADHD remains contested, the litigation has already faced major legal challenges, including a federal court decision granting summary judgment to defendants, which the plaintiffs have appealed