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Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family

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The emergence of the second peak is related to the limitations of the M2 protective mechanisms induced by lactylation and the excessive deterioration of the disease state, as studies have shown that this protective response does not completely counteract the M1-induced inflammatory microenvironmentthis transition begins with a delay and is relatively weak [47]

Wang YN, Meng XC, Dong YF, Zhao XH, Qian JM, Wang HY, Li JN (2019) Effects of probiotics and prebiotics on intestinal microbiota in mice with acute colitis based on 16S rRNA gene sequencing