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2 Key aspects of p53 function and regulation The p53 tumor suppressor plays a critical role in maintaining cellular homeostasis, by orchestrating responses to different types of stress and preventing malignant transformation ( Normally, cells maintain a modest level of p53 through a balance between its synthesis and degradation, while changes in p53 activity are primarily determined by post-translational modifications ( Figure 1 ) ( Figure 1 Under stress conditions, p53 activity is primarily modulated by posttranslational modifications within the TAD domain (24)

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