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Experimental sciatic nerve axotomy showed an axonal accumulation of A and promotion of the pathological formation of A plaques in the motor neurons in gray matter and the glial cells present in white and gray matter of the spinal cord, which may be a reactive response (Ahlgren et al., 1998)

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40 Cysteine availability has been shown to regulate extracellular glutamate concentrations, and thus neuronal excitability, via the cystineglutamate antiporter