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Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior

Every peptide synthesis carries a small percentage of deletion sequences, truncated fragments, or oxidized methionine residues

Notch signaling is activated by the binding of DLL1/3/4 or Jagged-like ligands (JLL1/2) to their receptors (Notch 14) leading to a conformational change