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Therefore, the enzymatic reaction of NQO1 catalyzes the conversion of duroquinone to hydroduroquinone, and the linked conversion of ferricyanide is reduced to ferrocyanide

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Increased PPAR degradation inhibited downstream fatty acid metabolism, leading to renal lipid accumulation, disrupted energy metabolism, and impaired kidney function

Human studies conducted to date generally involve small sample sizes, heterogeneous dosing regimens, and relatively short intervention periods, restricting the ability to draw robust conclusions regarding efficacy, optimal dosage, and treatment duration