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Next, JC-1, a dual emission cationic dye was used to indirectly evaluate changes in the mitochondrial membrane potential (MMP) (Fig

Our data strongly suggests that NatA depletion caused faster protein degradation by enhancing the endogenous ubiqitination rate and increasing the capacity of the proteasome as shown by enhanced abundance and activity of the proteasome in soluble protein extracts

In addition, IMiDs also enhance CD38 mAb-mediated ADCP by promoting the tumoricidal activity of macrophages [102]

Furthermore, IL-10 secreted by Breg cells can promote STAT3 phosphorylation and activate MDSCs, thus establishing a positive feedback loop