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Typical retention times [min] were: Cyd ( 1 ) 2.8, CMP ( 1a ) 3.3, CDP ( 1b ) 5.5, CTP ( 1c ) 12.9, dCyd ( 2 ) 2.6, dCMP ( 2a ) 3.4, dCDP ( 2b ) 6.3, dCTP ( 2c ) 14.5, araCyd ( 3 ) 3, araCMP ( 3a ) 3.5, araCDP ( 3b ) 6.2, araCTP ( 3c ) 13.7, 5F-Cyd ( 4 ) 2.8, 5F-CMP ( 4a ) 3.2, 5F-CDP ( 4b ) 5.4, 5F-CTP ( 4c ) 12.8, Ado ( 5 ) 5.9, AMP ( 5a ) 7.3, ADP ( 5b ) 14, ATP ( 5c ) 20.8, dAdo ( 6 ) 6.4, dAMP ( 6a ) 10.1, dADP ( 6b ) 17.3, dATP ( 6c ) 26.3, araAdo ( 7 ) 5.5, araAMP ( 7a ) - 8, araADP( 7b ) 15.5, araATP ( 7c ) 23, 2F-Ado ( 8 ) - 9, 2F-AMP ( 8a ) 12.8, 2F-ADP ( 8b ) 19.3, 2F-ATP ( 8c ) 29.9 (Supplementary Figures 2, 3)

Clearance - 850 ml/min

Toxicol Appl Pharmacol 2006

98 Recently, inhibition of DJ-1 (also known as PARK7-parkinsonism-associated deglycase) has been shown to enhance the sensitivity of tumor cells to ferroptosis induced by sorafenib and evaluated the antitumor activity of erastin in a xenograft nude mouse model via inhibition of the transsulfuration pathway and limiting the supply of cysteine