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All these results allowed to conclude that APR-246 induces early cell death by ferroptosis, a recently described non-apoptotic form of regulated cell death that links together membrane lipid peroxidation, cysteine and iron metabolism, glutathione peroxidase activity and oxidative stress (as summarized in Figure 4A 2325 )

Sern, AnnaKaisa Tuomaala, Johan Jendle, Pratik Choudhary, Emanuele Bosi, Viswanathan Mohan, Tim van den Heuvel, Ohad Cohen, Richard F

FEBS Lett 1991

In the context of ovarian aging, it activates SIRT1-dependent pathways, which are critical for maintaining genomic stability, mitochondrial efficiency, and cellular survival (Pasquariello et al., 2020)