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[19] [20] [21] However, several pieces of evidence also show that wild-type SOD1, under conditions of cellular stress, is implicated in a significant fraction of sporadic ALS cases, which represent 90% of ALS patients

Serotonin and noradrenaline modulators The modulation of serotonin and noradrenaline in the descending pain modulatory pathways of the central nervous system by agents such as low-dose tricyclic antidepressants and serotonin-noradrenaline reuptake inhibitors (SNRIs) can improve the clinical features of fibromyalgia independent of their effects on mood