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In a head-to-head trial against a full-strength GLP-1 drug, tirzepatide reduced food craving without changing measured restraint. Slower stomach emptying also makes smaller portions feel filling for longer. People whose eating was driven by stress, reward, or constant mental effort often describe the quiet as relief

Reverse-transcription quantitative PCR Colon tissues were homogenized in 600 l of lysis buffer via bead beating, and RNA was extracted using the GeneJET RNA Purification Kit (Thermo Scientific)