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Key Points Insulin-like growth factor 1 (IGF-I) is a useful screening test in children and young adults with growth-hormone deficiency IGF-I is not a stand-alone diagnostic test for growth-hormone deficiency in adults, and a confirmatory growth-hormone-stimulation test is required IGF-I can be used as a stand-alone diagnostic test for acromegaly Measurement of IGF-I at the time of diagnosis in acromegaly provides useful information on disease severity Monitoring the change in IGF-I levels during treatment of acromegaly provides a good index of the symptomatic response Growth hormone levels after glucose suppression, and IGF-I levels, are useful predictors of treatment success in acromegaly that correlate with long-term outcome This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF