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First characterized by Loren Pickart in 1973

Studies have shown reductions in seizure frequency in patients with drug-resistant epilepsy, likely due to modulation of excitability in epileptogenic zones ( 2

hCG is an FDA-approved hormone in clinical pharmaceutical formulations

As is known, in the Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease 2012 (KDIGO Guidelines), stage G1 of chronic kidney disease is defined by the presence of abnormalities of kidney structure or function, present for at least 3 months and not accompanied by GFR deterioration.45 Interestedly, the authors of the guidelines, among other functional alterations, included increased albuminuria but did not mention changes in the kidney's ability to manage water