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In a large trial, semaglutide 2.4 mg led to about 14.9% mean body-weight loss at 68 weeks versus 2.4% with placebo

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TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells

19 In brief, the samples were thawed on ice, briefly vortexed, and a 200-L aliquot was transferred to a clean microcentrifuge tube