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Furthermore, flow conditions that promote invasion of MDA-MB-231 aggregates in collagen gels trigger the upregulation of mesenchymal (Vimentin and Snail1) and epithelial (E-Cadherin and keratin-8) genes [237]

Both pathways rely on CD73 to convert AMP into the final product, namely adenosine ( + ( 2+ channel of endolysosomes to releases Ca 2+ , and Ca 2+ acts as the second messenger to promote angiogenesis, thus promoting tumor growth and metastasis ( 2+ by VEGFR2/NAADP/TPC2/Ca 2+ signaling pathway, which also leads to angiogenesis ( Figure 4 )

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