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[6] In the initial step, the specific activating protein (E1 or E1-like protein) activates Ubiquitin by adenylating it with ATP

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In our lung tumor patient cohort, rise in GAPDH abundance was positively correlated with glucose uptake of tumors and GLO1 oxidation, and negatively correlated with MG-H1 modification, sLG content as well as GLO1 abundance of tumors (Fig