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10.1136/bmjopen-2013-004216 BMJ Open 557 TuckerG

Ou J, Zhu X, Chen P, Du Y, Lu Y, Peng X, et al

"MOTS-c levels in human blood decline with age and correlate with insulin sensitivity, positioning the peptide not just as a metabolic tool but as a potential biomarker of mitochondrial vitality." On the exercise side, a pivotal finding came from studies measuring endogenous MOTS-c in human subjects