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The most common reason for misplaced injections was insufficient injection depth, which accounted for 36% of these cases

Furthermore, Xiong et al

171 Certain mutations of the methylenetetrahydrofolate reductase ( MTHFR ) gene are known to cause abnormal homocysteine metabolism, resulting in high homocysteine levels, and some studies have found these mutations may be more common in women with infertility