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This, in part, reflects the challenge and mistrust of the medical establishment, which worsened during the Covid pandemic, but was already showing strong signs of opposition by the wide adoption of supplements (with a very similar lack of supportive data on efficacy and safety) long before 2020

Individuals with high physical activity, intense cognitive work, or chronic stress may require higher or more frequent dosing

The clinical relevance of the treatment effect estimated using last observation on-treatment carried forward will be limited if trial participants tend to discontinue placebo earlier (or later) than participants in the active treatment group [4] since there is a risk of not comparing like with like in this type of analysis

This approach, which we've refined over years of working with researchers, delivers real results and minimizes error