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We prioritized evidence derived from human clinical trials, placing a distinct emphasis on randomized controlled trials (RCTs) and comprehensive systematic reviews published from 2015 onwards, reflecting the most recent and rigorous advancements in the field

Radomska KJ, Coulpier F, Gresset A, Schmitt A, Debbiche A, Lemoine S, et al

Preclinical evidence of Alzheimer's disease in persons homozygous for the 4 allele for apolipoprotein E

A close inspection of Fig 2 above reveals that the optimum temperature (the temperature that minimizes death rates) varies significantly from place to place