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This regulatory relationship highlights CHAC1s potential role in modulating oncogenic signaling pathways, making it a candidate for targeted therapy in diseases like uveal melanoma where PI3K/AKT signaling is dysregulated (Liu et al., 2019)

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Hence, NAD + rhythmic production has been proposed to finely tune the daily cycles of energy storage and utilization, as well as to align such processes with the rest-activity cycle