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The review found that oral and topical formulations demonstrate significant but variable melanin reduction with minimal side effects, while intravenous glutathione carries serious safety concerns including anaphylaxis and hepatotoxicity

10.1097/01.smj.0000202698.25909.97 45

Plant Physiol Biochem 57:1522 Molla MR, Ali MR, Hasanuzzaman M, Al-Mamun MH, Ahmed A, Nazim-Ud-Dowla MAN, Rohman MM (2014) Exogenous proline and betaine-induced upregulation of glutathione transferase and glyoxalase I in lentil ( Lens culinaris ) under drought stress