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Safety and Side Effects Common Side Effects The most commonly reported side effects of oral lysine supplementation are gastrointestinal in nature and dose-dependent: Diarrhea: Reported at doses of 1 gram or more daily [7][11] Abdominal pain and cramping: Reported at doses of 1 gram or more daily [7][11] Nausea: Occasionally reported, particularly when taken on an empty stomach at higher doses These side effects are generally mild and manageable by taking lysine with food or reducing the dose