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Even within the same prescription, acceptable manufacturing tolerances allow for slight variation

Different pathological patterns of white matter injury reflect different pathogenetic mechanisms of myelin and oligodendrocyte damage Although pathogenetic events that target myelin and oligodendrocytes invariably result in primary demyelination, the structural patterns of tissue injury in the initial stages of lesion formation differ, depending upon the mechanism involved

Suvarna KS, Layton C, Bancroft JD (2013) Bancrofts theory and practise of histological techniques, 7th edn

Current research models use 812 week cycles followed by 46 week breaks to prevent metabolic adaptation, though long-term human data is limited