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For first-time users, the published evidence base is strongest on topical at 1 to 2%

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Int J Mol Sci

RBD-scNPs provided sterilizing immunity in the upper airways of macaques and induced nAbs that could cross-recognize bat WIV-1, bat SHC014, SARS-CoV-1, and pangolin COV GXP4L viruses [131] as well as all SARS-CoV-2 variants tested [132]