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Scaffold repurposing reveals new nanomolar phosphodiesterase type 5 (PDE5) inhibitors based on pyridopyrazinone scaffold: Investigation of In vitro and in silico properties

mdpi.com A firstinhuman tolerability trial administering IV BPC-157 to healthy volunteers showed good safety profiles at doses up to 0.5 mg/kg, setting the stage for future clinical pharmacokinetic and safety assessments

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