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We assessed six rodent models of ASD as part of this translational study, and showed that the abnormality seen in individuals with ASDnamely a striatal glutamate deficitwas recapitulated in VPA-exposed mice, Nlgn3 R451C KI mice, and Nlgn3 KO rats

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These p62 condensates recruit and sequester Keap1, facilitating its degradation and inhibiting Keap1-mediated Nrf2 degradation

Additionally, we discovered that the presence of PI3K inhibitor significantly diminished the suppressive effect of SLC38A5 on MDA and ROS levels (Fig