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ATAC-Seq Gene Ontology Analyses Genomic coordinates for each DAR cluster ATAC-seq peaks were submitted to the GREAT 2.0.2 tool to determine if specific biological functions were enriched with differentially accessible regions at different times (25)

Long-term safety missing

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Sixth, the gut microbiota assessment was performed using culture-based methods, which provide targeted information on selected cultivable bacterial groups but do not capture the full microbial diversity or functional potential of the intestinal ecosystem