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Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice

Support for physical recovery

Similarly, SLC7A11 and SLC3A2, which are involved in amino acid transport and glutathione synthesis, respectively, were also down-regulated, further suggesting that the antioxidant mechanism is compromised [40, 41]

Disclosures: Farzaneh Tamnanloo: Nothing to Disclose, Quang Toan Pham: Nothing to Disclose, Marie-Agns MCallum: Nothing to Disclose, Denis Cyr: Nothing to Disclose, Paula Waters: Nothing to Disclose, Emilie Beaulieu: Nothing to Disclose, Yannick Doyon: Nothing to Disclose, Ugur Halac: Nothing to Disclose, Claudia Raggi: Nothing to Disclose, Massimiliano Paganelli: Morphocell Technologies: Executive role 2500 THE RELATIONSHIP BETWEEN SERUM BILE ACIDS AND EVENT-FREE SURVIVAL FOLLOWING THE USE OF MARALIXIBAT FOR PROGRESSIVE FAMILIAL INTRAHEPATIC CHOLESTASIS: DATA FROM MARCH/MARCH-ON Richard Thompson 1 Lorenzo D'Antiga 2 Simon Horslen 3 Douglas Mogul 4 Tiago Nunes 4 Will Garner 4 Pamela Vig 4 Alexander Miethke 5 , 1 King's College London, United Kingdom, 2 Papa Giovanni XXIII, Bergamo, Italy, 3 UPMC Children's Hospital of Pittsburgh, Pennsylvania, 4 Mirum Pharmaceuticals, Inc., Foster City, California, 5 Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio Background: Maralixibat, an inhibitor of the ileal bile acid transporter, is approved in the US for treatment of cholestatic pruritus in individuals 3 months with Alagille Syndrome (ALGS) and 5 years with Progressive Familial Intrahepatic Cholestasis (PFIC)