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Invasive delivery methods (e.g., intracerebral infusion or convection-enhanced delivery) improve local concentrations but introduce risks of hemorrhage, infection, and inconsistent distribution across the extensive dopaminergic axonal network

10.1093/ajcn/83.2.191 153 PhamV

Eventually, macrophages and extracellular protein-hydrolyzing enzymes remove clots and tissue debris to complete the repair process [164]

The hemolysis-derived heme could initiate inflammatory OxS that may cause microvascular thrombosis, organ ischemia and MODS in severe COVID-19 102,105