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On the other hand, ROS production is part of the cytotoxic mechanism of radiotherapy and mitochondria are very sensitive to ionizing radiation

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The acceptance of electrons by NADP will be reduced by using oxygen as an electron receptor, producing more ROS, such as 1 O 2 , , H 2 O 2 , and OH radicals, resulting in cell membrane peroxidation (Nikee et al., 2014)