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Thus, whilst we could obtain hits from both the NMR and XChem fragment screens, the cross-platform validation was generally limited, which prevented the rational design of larger, more potent analogues

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Further studies with larger sample sizes are required for a better understanding

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Here, c-MET is found to be preferentially overexpressed and activated along the peripheral tumour invasive front

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Growth factor upregulation (VEGF pathway): Also well-represented in the published literature

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