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The capacity of HGF to induce new synaptic connections and stimulate neurogenesis in the hippocampus supports the use of HGF mimetics for the treatment of depression

4.2 Detailed expandable studies Study 1: Heffernan 2001, foundational mechanism Citation: Heffernan M., Summers R.J., Thorburn A., et al

Observed molecular responses are dependent on experimental design, concentration, and model system, and are used to explore peptide-mediated regulatory mechanisms rather than defined physiological outcomes

The side-effect record is thinner than for FDA-approved drugs, so the picture below should be read as what has been reported , not what is known to be safe long-term