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Cysteine may be obtained from extracellular cysteine or cystine and, in some tissues, from the methionine cycle through the transsulfuration pathway

In cancer, including HCC, GLS1 is markedly upregulated and hyperactivated, and this elevation is strongly associated with poor prognosis [226, 227]

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In addition to their ability to load nucleic acid molecules, inorganic nanoparticles often possess unique functionalities, making them an attractive strategy for gene delivery [107,108,109,110]