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In vitro cytotoxicity has been observed at levels as low as 0.1 mg/litre

Am J Surg 248:116391, 2025

When tested in pancreatectomised dogs the first fraction stimulated secretion from the pancreas while the second seemed to lower blood glucose without activating secretion from the pancreas

All of these nutrients are harmless (and beneficial) to humans while poisonous to parasites, like the theobromine in chocolate is harmless to humans yet poisonous to dogs