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Patients with neurodegenerative diseases, post-COVID neurological fatigue, traumatic brain injury, or age-related neuroendocrine decline frequently experience treatment-resistant insomnia, indicating a need for therapeutic options that actively restore neurological integrity

10.1016/j.niox.2013.10.009 13 ChenX

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BPC 157 treatment led to the upregulation of Egr1, Akt1, Kras, Src, Foxo, Srf, Vegfr2, Nos3, and Nos1 and the downregulation of Nos2 and Nfkb compared with untreated rats