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In addition, isofistularin-3 could modify the methylation of the AHR promoter in Raji cells and induce growth arrest of cancer cells in G0/G1 concomitant with increased p21 and p27 expression and reduced cycling E1, PCNA, and c-myc levels (Florean et al., 2016)

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Recently, a fiber-hydrogel scaffold-mediated Cx43-AsODN delivery system was tested for the treatment of spinal cord injury and was shown to suppress reactive gliosis and reduce neuronal loss 507