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2017;26:55867.e5

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Cancer prevention by tea: Animal studies, molecular mechanisms and human relevance

For instance, LXR, a nuclear receptor for oxysterols, represses the expression of CYP51A1 and farnesyl-diphosphate farnesyltransferase 1 (FDFT1) in human HepG2 and HEK293 cells by binding to negative LXR response elements (nLXREs) in their promoters [39]