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However, due to the limitations of large-scale electrochemical equipment and large-area metal electrodes, electrochemical methods are generally not suitable for industrial production

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PLoS ONE 12(4):e0174474 Rahim I, Djerdjouri B, Sayed RK, Fernndez-Ortiz M, Fernndez-Gil B, Hidalgo-Gutirrez A et al (2017) Melatonin administration to wild-type mice and nontreated NLRP 3 mutant mice share similar inhibition of the inflammatory response during sepsis

Non-enzymatic S-glutathionylation reactions are classically viewed as occurring when the 2GSH/GSSG ratio is ~1, e.g., during oxidative stress (Ziegler, 1985