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The FDAs framework is prospective and dataset-driven, and the gap between accumulated clinical experience in compounding practice and formal regulatory confidence in a substance is a defining feature of the peptide therapeutic category

doi: 10.1080/09638288.2017.1383518 583 KoenigJESporAScalfoneNFrickerADStombaughJKnightRet al

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Nausea: Uncommonly reported, usually with higher doses