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B12 deficiency can occur due to several factors, including: Age : Absorption of B12 declines with age, especially in individuals over 60

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There are many documented clinical cases, all of them varied, with a multitude of symptoms, combinations of several of them, and uncertain onset, and with relatively good responses to treatment, but sometimes with very serious consequences if action is delayed: pancytopenia, organ failure, partial or permanent vision loss that is not recovered, heart attacks, and death