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Tamoxifen suppresses paclitaxel-vincristine-and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway

Two important proteins whose function is affected by Pb 2+ are calmodulin, a Ca-binding multifunctional calcium-binding messenger protein, and protein kinase C (PKC), a family of serine/threonine protein kinases that regulate various cellular functions, including Ca-mediated signal transduction (Goodsell 2016)

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