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For instance, although pathogenic mtDNA mutations impair cellular metabolism and cause cellular heterogeneity and disease, recent studies have unravelled that different mutations are associated with different clinical phenotypes and that purification choices of T cells also affect pathogenic mtDNA mutations in vivo , which has not been widely validated in RA and still needs to be further explored in the future ( To date, all available findings support the use of mitochondria as a breakthrough point in combating RA, and even some researchers have attempted to develop targeted therapeutic strategies