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While Nrf2 and JAK2/STAT3 have protective roles, severe oxidative stress can also lead to their dysregulation or interaction with other pathways in ways that contribute to later-stage remodeling or inflammation (Mahdiani et al., 2022

They also clarified in another clinical study that supplements with glycine (1.33 mmol/kg/day) and N-acetylcysteine (0.81 mmol/kg/day) for 24 weeks corrected erythrocyte-GSH deficiency and alleviated oxidative stress and mitochondrial dysfunction in elderly individuals [110]