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In addition, Klotho also exerts FGF23 independent effects

10.3389/fmed.2022.1052792 161 WuD.LuoY.LiT.ZhaoX.LvT.FangG.et al (2022)

It is now well known that A is an antimicrobial peptide, released by neural cells in response to infectious agents 12,13 , so it is not surprising that the presence of bacteria in the brain can result in A deposition reviewed in 8