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Due to spin constraints, molecular O 2 cannot accept four electrons simultaneously to produce a water molecule

Int J Tryptophan Res (2009) 2:4560

While good responders ( n = 4) achieved complete remission (CR) or a complete remission with incomplete hematologic recovery (CRI), poor responders ( n = 10) only reached cytoreduction or stable disease after Venetoclax treatment (Supplementary Table 1)

Adding to the complexity, these patients may also have concurrent conditions such as hip dysplasia, degenerative joint disease (DJD), and lumbosacral disease